Recent vision and multimodal foundation backbones, such as Transformer families and state-space models like Mamba, have achieved remarkable progress, enabling unified modeling across images, text, and beyond. Despite their empirical success, these architectures remain far from the computational principles of the human brain, often demanding enormous amounts of training data while offering limited interpretability. In this work, we propose the Vision Hopfield Memory Network (V-HMN), a brain-inspired foundation backbone that integrates hierarchical memory mechanisms with iterative refinement updates. Specifically, V-HMN incorporates local Hopfield modules that provide associative memory dynamics at the image patch level, global Hopfield modules that function as episodic memory for contextual modulation, and a predictive-coding-inspired refinement rule for iterative error correction. By organizing these memory-based modules hierarchically, V-HMN captures both local and global dynamics in a unified framework. Memory retrieval exposes the relationship between inputs and stored patterns, making decisions more interpretable, while the reuse of stored patterns improves data efficiency. This brain-inspired design therefore enhances interpretability and data efficiency beyond existing self-attention- or state-space-based approaches. We conducted extensive experiments on public computer vision benchmarks, and V-HMN achieved competitive results against widely adopted backbone architectures, while offering better interpretability, higher data efficiency, and stronger biological plausibility. These findings highlight the potential of V-HMN to serve as a next-generation vision foundation model, while also providing a generalizable blueprint for multimodal backbones in domains such as text and audio, thereby bridging brain-inspired computation with large-scale machine learning.

Extensive experimental results show that our method generalizes well for arbitrary groups ofclients and provides largeperformance improvements giventhe same overall communication/computation resources, compared to other baselines relying on knownpretrainingmethods.

Federated Learning (FL) is a machine learning paradigm that allows decentralized clients to learn collaboratively without sharing their private data. However, excessivecomputation and communication demands pose challenges to current FL frameworks, especially when training large-scale models.

Personalized Federated Learning (PFL) faces persistent challenges, including domain heterogeneity from diverse client data, data imbalance due to skewed participation, and strict communication constraints. Traditional federated learning often lacks personalization, as a single global model cannot capture client-specific characteristics, leading to biased predictions and poor generalization, especially for clients with highly divergent data distributions. To address these issues, we propose FedSTAR, a style-aware federated learning framework that disentangles client-specific style factors from shared content representations. FedSTAR aggregates class-wise prototypes using a Transformer-based attention mechanism, allowing the server to adaptively weight client contributions while preserving personalization. Furthermore, by exchanging compact prototypes and style vectors instead of full model parameters, FedSTAR significantly reduces communication overhead. Experimental results demonstrate that combining content-style disentanglement with attention-driven prototype aggregation improves personalization and robustness in heterogeneous environments without increasing communication cost.

Federated learning (FL) enables collaborative training of a global model in the centralized server with data from multiple parties while preserving privacy. However, data heterogeneity can significantly degrade the performance of the global model when each party uses datasets from different sources to train a local model, thereby affecting personalized local models. Among various cases of data heterogeneity, feature drift, feature space difference among parties, is prevalent in real-life data but remains largely unexplored. Feature drift can distract feature extraction learning in clients and thus lead to poor feature extraction and classification performance. T o tackle the problem of feature drift in FL, we propose FedPall, an FL framework that utilizes prototype-based adversarial learning to unify feature spaces and collaborative learning to reinforce class information within the features. Moreover, FedPall leverages mixed features generated from global prototypes and local features to enhance the global classifier with classification-relevant information from a global perspective. Evaluation results on three representative feature-drifted datasets demonstrate FedPall's consistently superior performance in classification with feature-drifted data in the FL scenario.

Prototype-based neural networks offer interpretable predictions by comparing inputs to learned, representative signal patterns anchored in training data. While such models have shown promise in the classification of physiological data, it remains unclear whether their prototypes capture an underlying structure that aligns with broader clinical phenotypes. We use a prototype-based deep learning model trained for multi-label ECG classification using the PTB-XL dataset. Then without modification we performed inference on the MIMIC-IV clinical database. We assess whether individual prototypes, trained solely for classification, are associated with hospital discharge diagnoses in the form of phecodes in this external population. Individual prototypes demonstrate significantly stronger and more specific associations with clinical outcomes compared to the classifier's class predictions, NLP-extracted concepts, or broader prototype classes across all phecode categories. Prototype classes with mixed significance patterns exhibit significantly greater intra-class distances (p $<$ 0.0001), indicating the model learned to differentiate clinically meaningful variations within diagnostic categories. The prototypes achieve strong predictive performance across diverse conditions, with AUCs ranging from 0.89 for atrial fibrillation to 0.91 for heart failure, while also showing substantial signal for non-cardiac conditions such as sepsis and renal disease. These findings suggest that prototype-based models can support interpretable digital phenotyping from physiologic time-series data, providing transferable intermediate phenotypes that capture clinically meaningful physiologic signatures beyond their original training objectives.

Deep learning-based electrocardiogram (ECG) classification has shown impressive performance but clinical adoption has been slowed by the lack of transparent and faithful explanations. Post hoc methods such as saliency maps may fail to reflect a model's true decision process. Prototype-based reasoning offers a more transparent alternative by grounding decisions in similarity to learned representations of real ECG segments, enabling faithful, case-based explanations. We introduce ProtoECGNet, a prototype-based deep learning model for interpretable, multi-label ECG classification. ProtoECGNet employs a structured, multi-branch architecture that reflects clinical interpretation workflows: it integrates a 1D CNN with global prototypes for rhythm classification, a 2D CNN with time-localized prototypes for morphology-based reasoning, and a 2D CNN with global prototypes for diffuse abnormalities. Each branch is trained with a prototype loss designed for multi-label learning, combining clustering, separation, diversity, and a novel contrastive loss that encourages appropriate separation between prototypes of unrelated classes while allowing clustering for frequently co-occurring diagnoses. We evaluate ProtoECGNet on all 71 diagnostic labels from the PTB-XL dataset, demonstrating competitive performance relative to state-of-the-art black-box models while providing structured, case-based explanations. To assess prototype quality, we conduct a structured clinician review of the final model's projected prototypes, finding that they are rated as representative and clear. ProtoECGNet shows that prototype learning can be effectively scaled to complex, multi-label time-series classification, offering a practical path toward transparent and trustworthy deep learning models for clinical decision support.

Prototype-based federated learning (PFL) has emerged as a promising paradigm to address data heterogeneity problems in federated learning, as it leverages mean feature vectors as prototypes to enhance model generalization. However, its robustness against backdoor attacks remains largely unexplored. In this paper, we identify that PFL is inherently resistant to existing backdoor attacks due to its unique prototype learning mechanism and local data heterogeneity. To further explore the security of PFL, we propose BAPFL, the first backdoor attack method specifically designed for PFL frameworks. BAPFL integrates a prototype poisoning strategy with a trigger optimization mechanism. The prototype poisoning strategy manipulates the trajectories of global prototypes to mislead the prototype training of benign clients, pushing their local prototypes of clean samples away from the prototypes of trigger-embedded samples. Meanwhile, the trigger optimization mechanism learns a unique and stealthy trigger for each potential target label, and guides the prototypes of trigger-embedded samples to align closely with the global prototype of the target label. Experimental results across multiple datasets and PFL variants demonstrate that BAPFL achieves a 35\%-75\% improvement in attack success rate compared to traditional backdoor attacks, while preserving main task accuracy. These results highlight the effectiveness, stealthiness, and adaptability of BAPFL in PFL.